George YC Wong, Ph.D.
Preventive Oncology Research

Head, Preventive Oncology Research, Strang Cancer Prevention Center
Professor, Department of Surgery, Weill Medical College of Cornell University

The primary aims of our research are: 1) to evaluate natural substances and herbs for chemoprevention of breast, colon, and prostate cancers; 2) to conduct intervention trials using promising nutritional substances on subjects at increased risk for one of these cancers; and 3) to perform statistical risk assessments on subjects at increased risk for one of these cancers.

Our ongoing research projects include:

1. A statistical model for estimating lifetime breast cancer risk for women at increased risk for the disease.

2. Statistical issues in the conduct of a chemopreventive trial involving an endocrine biomarker.

3. A randomized, placebo-controlled intervention trial to investigate the efficacy of indole-3-carbinol in preventing breast cancer using an endocrine intermediate biomarker.

Keywords:
Chemoprevention, intermediate biomarkers, nutritional intervention trials

Deschner, E.E., Ruperto, J.F., Wong, G.Y., and Newmark, H.L. (1993) The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutr. Cancer, 20:199-204.

Lipkin, M., Bhandari, M., Hakissian, M., Croll, W., and Wong, G.Y. (1994) Surrogate endpoint biomarker assays in phase II chemoprevention clinical trials. J. Cell. Biochem. Suppl., 19:47-54.

Bradlow, L.H., Michnovicz, J.J., Halper, M., Miller, D.G., Wong, G.Y., and Osborne, M.P. (1994) Long-term responses of women to indole-3-carbinol or high fiber diet. Cancer Epidemiol. Biomarkers Prev., 3:591-595.