Michael P. Osborne, M.D.
Iris Cantor Clinical Research Unit

President/CEO
Strang Cancer Prevention Center

Professor, Department of Surgery
Weill Medical College of Cornell University


Research Summary
Recent Publications
Contact Information


RESEARCH SUMMARY

Hormonal, genetic, and nutritional factors in cancer prevention

The primary aims of our research in the field of breast cancer involve examining the hormonal, genetic, and nutritional factors which affect the prevention, early detection, and treatment of the disease.

Ongoing projects in our laboratories at Strang Cancer Prevention Center involve:

1. Prevention of human breast cancer.
We are utilizing the newly developed explant culture/cell culture model and newly identified biomarkers to examine whether naturally-occurring dietary agents inhibit preneoplastic transformation and suppress the risk of developing breast cancer. These studies attempt to validate a clinically relevant experimental model for screening potential carcinogens and efficacious chemopreventive agents.

2. Identification of tissue markers in occult bone marrow micrometastasis.
We are attempting to define the relationship between the presence of cytokeratin positive (micrometastic) cells in the bone marrow and the primary breast tumor characteristics, with an assumption that the micrometastatic epithelial cells in the marrow are a subset of aggressive primary tumor cells.

 

Keywords: Breast cancer, prevention/early detection, micrometastasis, chemoprevention


PUBLICATIONS



1. Osborne MP, Paneth M, Hinson KFW.
Starch granules in the pericardium as a cause of post-cardiotomy syndrome.
Thorax 1974;29:199-203

2. Osborne MP.
Penile Parkinsonism.
Postgraduate Medical Journal 1974;50:523-524

3. Honey M, Lincoln JCR, Osborne MP, DeBono D.
Coarctation of the aorta with right aortic arch.
British Heart Journal 1975;37:937-945

4. Osborne MP, Hamilton G, Shalley M.
Axial volvulus of Meckel's diverticulum.
Postgraduate Medical Journal 1978;54:692-693

5. Bion J, Coleman JC, Osborne MP.
An unusual postoperative pneumonia.
Journal of the Royal Society of Medicine 1978;71:523-526

6. Ryman BE, Jewkes RF, Jeyasingh K, Osborne MP, Patel HM, Richardson VJ, Tyrell DA.
Potential applications of liposomes to therapy.
Annals of the New York Academy of Sciences 1978;308:281-307

7. Osborne MP, Murray-Lyon IM, Reynolds K.
Dacron bypass grafting in the relief of obstructive jaundice.
Lancet 1979;1:1323-1325

8. Osborne MP, Richardson VJ, Jeyasingh K, Ryman BE.
Radionuclide labeled liposomes - a new lymph node imaging agent.
International Journal of Nuclear Medicine and Biology 1979;6:75-83

9. Osborne MP, Jeyasingh K, Jewkes RF, Burns JI.
The preoperative detection of internal mammary lymph node metastases in breast cancer.
British Journal of Surgery 1979;66:813-818

10. Osborne MP.
Lymph node scanning for breast cancer.
Transactions of the Medical Society of London 1979;95:43-45

11. Greening WP, Sarker SK, Osborne MP.
Hemiagenesis of the thyroid gland.
British Journal of Surgery 1980;67:446-448

12. Sarker SK, Osborne MP, Harmer CL, Greening WP.
Thyroid cancer - a study of 220 cases.
Indian Journal of Cancer 1980;17:11-18

13. Osborne MP.
The detection of lymphatic metastases in breast cancer.
Master of Surgery Thesis, University of London, 1980

14. Osborne MP, Richardson VJ, Jeyasingh K, Ryman BE.
Potential applications of radionuclide-labeled liposomes in the detection of the lymphatic spread of cancer.
International Journal of Nuclear Medicine, Biology and Physics 1982;9:47-51

15. Osborne MP, Griffiths JD, Shaw HJ.
Colon-transposition in the management of upper gastrointestinal cancer.
Cancer 1982;50:257-264

16. Freeman JL, Brondbo K, Osborne MP, Novek AM, Shaw HJ, Rubin A, Chapnick JS.
Greater momentum used for carotid cover after pharyngolaryngoesophagectomy and gastric "pull-up" or colonic "swing".
Archives of Otolaryngology 1982;108:685-687

17. Osborne MP, Payne JH, Richardson VJ, McCready VR, Ryman BE.
The preoperative detection of axillary lymph node metastases in breast cancer by isotope imaging. British Journal of Surgery 1983;70:141-144

18. Osborne MP.
Pedal microlymphangiography in the experimental animal.
Lymphology 1983;16:31-34

19. Osborne MP, Rosen PP, Lesser ML, Schwartz MK, Menendez-Botet CJ, Fishman J, Kinne DW,
Beattie EJ Jr.
The relationship between family history, exposure to exogenous hormones and estrogen receptor protein in breast cancer.
Cancer 1983;51:2134-2138

20. Fracchia AA, Cody HS, Eisenberg BL, Osborne MP, Owens JC, Weingrad DN, Caron AS,
Urmacher C, Bretsky S.
Stage II carcinoma of the breast: The importance of adequate local therapy.
Breast 1983;9:23-29

21. Osborne MP, Ormiston N, Harmer CL, McKinna JA, Baker J, Greening WP.
Breast conservation in the treatment of early breast cancer: A 20-year follow-up.
Cancer 1984;53:349-355

22. Petrek JA, Dukoff R, Crowe J, Osborne MP, Kinne DW.
Pregnancy-associated breast cancer.
Surgical Forum 1986;38:478-480

23. Axelrod DM, Bockman RS, Wong GY, Osborne MP, Kinne DW, Brennan MF.
Distinguishing features of primary hyperparathyroidism in patients with breast cancer.
Cancer 1987;60:160-1624

24. McCormick B, Kinne D, Petrek J, Osborne MP, Cox L, Shank B, Hellman S, Yahalom J, Rosen PP.
Limited resection for breast cancer: A study of inked specimen margins before radiotherapy.
International Journal of Radiation Oncology, Biology, Physics 1987;13:1667-1671

25. Cote RJ, Rosen PP, Hakes TB, Sedira M, Bazinet M, Kinne DW, Old LJ, Osborne MP.
Monoclonal antibodies detect occult breast carcinoma metastases in the bone marrow of patients with early stage disease.
American Journal of Surgical Pathology 1988;12:333-340

26. Axelrod DM, Menendez-Botet CJ, Kinne DW, Osborne MP.
Levels of estrogen and progesterone receptor proteins in patients with breast cancer during various phases of the menstrual cycle.
Cancer Investigation 1988;6:7-14

27. Wesson MF, Osborne MP, Petrek J, Kinne D, McCormick B.
Iridium-192 implants for primary breast cancer: Experience with concomitant limited resection or re-excision.
Endocurietherapy/Hyperthermia Oncology 1988;4:149-153

28. McCormick B, Wesson MF, Cox L, Osborne MP, Petrek JA, Kinne DW.
Iridium-192 implants for primary breast cancer: Experience with placement at the time of wide local excision.
International Journal of Radiation Oncology, Biology and Physics 1988;15:745-748

29. Telang NT, Basu A, Kurihara H, Osborne MP, Modak MJ.
Modulation in the expression of murine mammary tumor virus, ras proto-oncogene and of alveolar hyperplasia by fatty acids in mouse mammary explant cultures.
Anticancer Research 1988;8:971-976

30. Osborne MP, Karmali RA, Hershcopf RJ, Bradlow HL, Kourides IA, Williams WR, Rosen PP,
Fishman J.
Omega-3 fatty acids: modulation of estrogen metabolism and potential for breast cancer prevention.
Cancer Investigation 1988;6:629-631

31. Dermatis H, Rowland J, Miransky J, Kerner J, Osborne MP, Holland J.
Consent and compliance in chemoprevention trials.
Cancer Investigation 1988;6:633-635

32. Kinne DW, Petrek JA, Osborne MP, Fracchia AA, DePalo AA, Rosen PP.
Breast carcinoma in-situ.
Archives of Surgery 1989;124:33-36

33. Osborne MP, Asina S, Wong GY, Old LJ, Cote RJ.
Immunofluorescent monoclonal antibody detection of breast cancer in bone marrow: a study of sensitivity in a model system.
Cancer Research 1989;49:2510-2513

34. Telang NT, Bradlow HL, Kurihara H, Osborne MP.
In vitro biotransformation of estradiol by explant cultures of murine mammary tissues.
Breast Cancer Research and Treatment 1989;13:173-181

35. Baron PL, Moore MP, Kinne DW, Candela FC, Osborne MP, Petrek JA.
Occult breast cancer presenting with axillary metastases: updated management.
Archives of Surgery 1990;125:210-215

36. Osborne MP, Telang NT, Kaur S, Bradlow HL.
Influence of chemo-preventive agents, tamoxifen and hydroxyphenylretinamide (HPR) on estradiol metabolism and mammary preneoplasia in C3H mice.
Steroids 1990;55:114-119

37. Telang NT, Axelrod DM, Bradlow HL, Osborne MP.
Metabolic biotransformation of estradiol in human mammary explant cultures.
Annals of the New York Academy of Sciences 1990;586:70-78

38. Telang NT, Basu A, Modak MJ, Osborne MP.
Cellular ras proto-oncogene expression in human mammary explant cultures: A potential marker for chemical carcinogenesis.
Annals of the New York Academy of Sciences 1990;586:230-237

39. Telang NT, Osborne MP, Sweterlitsch LA, Narayanan R.
Neoplastic transformation of mouse mammary epithelial cells by deregulated myc expression.
Cell Regulation 1990;1:863-872

40. Dershaw DD, McCormick B, Cox L, Osborne MP.
Differentiation of benign and malignant local tumor recurrence after lumpectomy.
American Journal of Roentgenology 1990;155:35-38

41. Seres DS, Bunk MJ, Osborne MP, Rivlin RS, Tiwari RK.
Effects of marginal dietary zinc deficiency and vitamin E supplementation on hepatic adenine dinucleotide phosphoribosyl transferase activity in female Sprague-Dawley rats.
Nutrition Research 1991;11:337-345

42. Telang NT, Axelrod DM, Wong GY, Bradlow HL, Osborne MP.
Biotransformation of estradiol by explant cultures of human breast tissue.
Steroids 1991;56:37-43

43. Dershaw DD, Panicek DM, Osborne MP.
Significance of lymph nodes visualized by the mammographic axillary view.
Breast Diseases 1991;4:271-280

44. Tiwari RK, Wong GY, Mukhopadhyay B, Telang NT, Liu J, Hakes TB, Osborne MP.
Interferon-alpha and gamma mediated gene responses in a human breast carcinoma cell line.
Breast Cancer Research and Treatment 1991;18:33-41

45. Osborne MP, Asina S, Wong GY, Old LJ, Cote RJ, Rosen PP.
Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow.
Cancer Research 1991;51:2706-2709

46. Telang NT, Narayanan R, Bradlow HL, Osborne MP.
Coordinated expression of intermediate biomarkers for tumorigenic transformation in ras-transfected mouse mammary epithelial cells.
Breast Cancer Research and Treatment 1991;18:155-163

47. Cote RJ, Rosen PP, Lesser ML, Old LJ, Osborne MP.
Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases.
Journal of Clinical Oncology 1991;9:1749-1756

48. Telang NT, Kurihara H, Wong GY, Bradlow HL, Osborne MP.
Preneoplastic transformation in mouse mammary tissue: identification and validation of intermediate biomarkers for chemoprevention.
Anticancer Research 1991;11:1021-1028

49. Michnovicz JJ, Telang NT, Osborne MP, Bradlow HL.
Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.
Carcinogenesis 1991;12:1571-1574

50. Tiwari RK, Mukopadhyay B, Telang NT, Osborne MP.
Modulation of gene expression by selected fatty acids in human breast cancer cells.
Anticancer Research 1991;11:1383-1388

51. Tiwari RK, Wong GY, Liu I, Miller D, Osborne MP.
Augmentation of cytotoxicity using combinations of interferon (types I and II), tumor necrosis factor and tamoxifen in MCF-7 cells.
Cancer Letters 1991;61:45-52

52. Osborne MP, Borgen PI, Wong GY, Rosen PP, McCormick B.
Salvage mastectomy for local-regional relapse after breast conserving surgery and radiation therapy. Surgery, Gynecology and Obstetrics 1992;174:189-194

53. Osborne MP, Ruperto JF, Crowe JP, Rosen PP, Telang NT.
The effect of tamoxifen on preneoplastic cell proliferation in N-nitroso-N-methylurea-induced mammary carcinogenesis.
Cancer Research 1992;52:1477-1480

54. Narayanan R, Lawlor KG, Schaapveld RQJ, Cho KR, Vogelstein B, Tran PB-V, Osborne MP,
Telang NT.
Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts.
Oncogene 1992;7:553-561

55. Telang NT, Suto A, Wong GY, Osborne MP, Bradlow HL.
Induction by estrogen metabolite 16a-hydroxestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells.
Journal of the National Cancer Institute 1992;84:634-636

56. Tiwari RK, Borgen PI, Cordon-Cardo C, Osborne MP.
HER-2/neu amplification and overexpression in primary human breast cancer is associated with early metastasis.
Anticancer Research 1992;12:419-426

57. Willard W, Borgen P, Bol R, Tiwari R, Osborne MP.
Cowden's Disease: A case report with analyses at the molecular level.
Cancer 1992;69:2969-2974

58. Suto A, Bradlow HL, Wong GY, Osborne MP, Telang NT.
Persistent endocrine responsiveness of ras oncogene-transformed mouse mammary epithelial cells.
Steroids 1992;57:262-268

59. Telang NT, Bradlow HL, Osborne MP.
Molecular and endocrine biomarkers in non-involved breast: relevance to cancer chemoprevention.
Journal of Cellular Biochemistry 1992;16:161-169

60. Borgen PI, Vlamis V, Potter C, Hoffman B, Wong GY, Kinne DW, Osborne MP, McKinnon WMP.
Current management of male breast cancer: A review of 104 cases.
Annals of Surgery 1992;215:451-459

61. Lawler KG, Telang NT, Osborne MP, Schaapveld RQ, Cho KR, Vogelstein B, Narayanan R.
Antisense RNA to the putative tumor suppressor gene "Deleted in Colorectal Cancer" transforms fibroblasts.
Annals of the New York Academy of Sciences 1992;660:283-285

62. Yahalom J, Petrek JA, Biddinger PW, Kessler S, Dershaw DD, McCormick B, Osborne MP, Rosen PP.
Breast cancer in patients irradiated for Hodgkin’s disease: A clinical and pathological analysis of 45 events in 37 patients.
Journal of Clinical Oncology 1992;10:1674-1681

63. Tiwari RK, Mukhopadhyay B, Osborne MP.
Desensitization of human breast cancer cells by interferon.
International Journal of Oncology 1992;1:601-605

64. Dershaw DD, McCormick B, Osborne MP.
Detection of local recurrence after conservation therapy for breast carcinoma.
Cancer 1992;70:493-496

65. Bradlow HL, Michnovicz JJ, Telang NT, Osborne MP, Goldin BR.
Diet, oncogenes and tumor viruses as modulators of estrogen metabolism in vivo and in vitro.
Cancer Prevention and Detection 1992;16:1 S38-S42

66. Suto A, Bradlow HL, Kubota T, Kilajma M, Wong GY, Osborne MP, Telang NT.
Alterations in proliferative and endocrine responsiveness of human mammary carcinoma cells by prototypic tumor suppressing agents.
Steroids 1993;58:215-219

67. Breuer B, Kash K, Rosenthal G, Diemer K, Osborne MP, Miller DG.
Reporting bilaterality status in first-degree relatives with breast cancer: A validity study.
Genetic Epidemiology 1993;10:245-256

68. Tiwari RK, Guo L, Mukhopadhyay B, Wong GY, Osborne MP.
Gene induction by interferons in BT-20 cells.
International Journal of Oncology 1993;481-487

69. Garg A, Suto A, Osborne MP, Gupta RC, Telang NT.
Expression of biomarkers for transformation in 7,12-dimethylbenz[a]anthracene-treated mammary epithelial cells.
International Journal of Oncology 1993;3:185-189

70. Breuer B, Luo J, DeVivo I, Pincus M, Tatum AH, Daucher J, Minick R, Osborne MP, Miller DG, Nowak E, Cody H, Carney WP, Brandt-Rauf PW.
Detection of elevated c-erbB-2 oncoprotein in the serum and tissue in breast cancer.
Medical Science Research 1993;21:383-384

71. DeVivo I, Breuer B, Smith S, Milling C, Pincus M, Tatum AH, Daucher J, Niman H, Minick R, Osborne MP, Miller DG, Nowak E, Cody H, Brandt-Rauf PW.
Detection of serum c-myc oncoprotein in cancer patients by immunoblot.
Medical Science Research 1993;21:345-347

72. Osborne MP, Bradlow HL, Wong GYC, Telang NT.
Upregulation of estradiol C16?-hydroxylation in human breast tissue: A potential biomarker of breast cancer risk.
Journal of the National Cancer Institute 1993;85:1917-1920

73. Suto A, Bradlow HL, Wong GYC, Osborne MP, Telang NT.
Experimental down-regulation of intermediate biomarkers of carcinogenesis in mouse mammary epithelial cells.
Breast Cancer Research and Treatment 1993;27:193-202

74. Tiwari RK, Guo L, Bradlow HL, Telang NT, Osborne MP.
Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent.
Journal of the National Cancer Institute 1994;86:126-131

75. Sepkovic DW, Bradlow HL, Michnovicz J, Murtezani S, Levy I, Osborne MP.
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol, ascorbigen, or B-naphthaflavone: A comparison of stable isotope dilution gas chromatography-mass spectrometry and radiometric methods.
Steroids 1994;59:318-322

76. Telang NT, Bradlow HL, Osborne MP.
Effect of tamoxifen on mammary preneoplasia: Relevance to chemopreventive intervention
Cancer Detection and Prevention 1994;18:313-321

77. Osborne MP, Rosen PP.
Detection and management of bone marrow micrometastases in breast cancer.
Oncology 1994;8:25-31

78. Kash KM, Holland JC, Miller DG, Osborne MP.
Psychological distress and adherence to screening behaviors in women at genetic risk for breast cancer.
Psychosomatic Medicine 1994;56:148-149

79. Bradlow HL, Michnovicz JJ, Halper M, Miller DG, Wong GY, Osborne MP.
Long-term responses of women to indole-3-carbinol or a high fiber diet.
Cancer Epidemiology Biomarkers and Prevention 1994;3:591-595

80. Osborne MP, Simmons RM.
Salvage surgery for recurrence after breast conservation.
World Journal of Surgery 1994;18:93-97

81. Shattuck-Eidens D, McClure M, Simard J, Labrie F, Narod S, Couch F, Hoskins K, Weber B, Castilla L, Erdos M, Brody L, Friedman L, Ostermeyer E, Szabo C, King MC, Jharwar S, Offit K, Norton L, Gilewski T, Lubin M, Osborne MP, Black D, Boyd M, Steel M, Ingles S, Haile R, Lindblom A, Olsson H, Borg A, Bishop DT, Solomon E, Radice P, Spatti G, Gayther S, Ponder B, Warren W, Stratton M, Liu Q, Fujimura F, Lewis C, Skolnick M, Goldgar E.
A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene.
Journal of the American Medical Association 1995;273:535-541

82. Valdimarsdottir HB, Bovbjerg DH, Kash KM, Holland JC, Osborne MP, Miller DG.
Psychological distress in women with a familial risk of breast cancer.
Psycho-Oncology 1995;4:133-141

83. Li G, Osborne MP, Tiwari RK.
Anti-proliferative effects of garlic constituents in cultured human breast cancer cells.
Oncology 1995;2:787-791

84. Fishman J, Osborne MP, Telang NT.
The role of estrogen in mammary carcinogenesis.
Annals of the New York Academy of Sciences 1995;768:91-100

85. Araki R, Inoue S, Osborne MP, Telang NT.
Chemoprevention of mammary preneoplasia. In-vitro effects of a green tea polyphenol.
Annals of the New York Academy of Sciences 1995;768:215-222

86. Kash KM, Holland JC, Osborne MP, Miller DG.
Psychological counseling strategies for women at risk of breast cancer.
Journal of the National Cancer Institute, Monogr. 1995;17:73-79

87. Sepkovic DW, Bradlow HL, Ho G, Hankinson SE, Gong L, Osborne MP, Fishman J.
Estrogen metabolite ratios and risk assessment of hormone-related cancers. Assay validation and prediction of cervical cancer risk.
Annals of the New York Academy of Sciences 1995;768:312-316

88. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP.
Indole-3-carbinol. A novel approach to breast cancer prevention.
Annals of the New York Academy of Sciences 1996;768:180-200


89. Osborne MP.
Hormonal intervention in breast cancer: Past, present and future.
Annals of the New York Academy of Sciences 1996;784:427-432

90. Arzimanoglou II, Lallas T, Osborne MP, Barber H, Gilbert F.
Microsatellite instability differences between familial and sporadic ovarian cancers.
Carcinogenesis 1996;9:1799-1804

91. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP.
2-Hydroxyestrone: the ‘good’ estrogen.
Journal of Endocrinology 1996;150:S259-S265

92. Fishman JH, Gonzalez A, Osborne MP.
Breast cancer cells cultured in a system of new design presecrete an extracellular matrix and proliferate within it without cell-cell adhesion.
Biochemical and Biophysical Research Communication 1996;220:467-471

93. Bradlow L, Telang NT, Osborne MP.
Estrogen metabolites as bioreactive modulators of tumor initiators and promoters.
Advances in Experimental Medical Biology 1996;387:285-296

94. Katdare M, Singhal H, Newmark H, Osborne MP, Telang NT.
Prevention of mammary preneoplastic transformation by naturally-occurring tumor inhibitors.
Cancer Letter 1997;111:141-147

95. Telang NT, Katdare M, Bradlow HL, Osborne MP.
Estradiol metabolism: An endocrine biomarker for modulation of human mammary carcinogenesis.
Environmental Health Perspectives 1997;105 Suppl:559-564

96. Singhal H, Potter C, Osborne MP.
No effect of timing of biopsy in the menstrual cycle on incidence of bone marrow micrometastasis in patients with breast cancer.
Annals of Surgical Oncology 1997; 4:503-505

97. Telang NT, Katdare M, Bradlow HL, Osborne MP, Fishman J.
Inhibition of proliferation and modulation of estradiol metabolism: Novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol.
Proceedings of the Society for Experimental Biology and Medicine 1997; 216:246-252

98. Simmons RM, Osborne MP.
Dilemmas in breast disease: Prophylactic mastectomy.
Breast Journal 1997;3:372-379

99. Zakowski SG, Valdimardottir HB, Bovbjerg DH, Borgen P, Holland J, Kash K, Miller DG, Mitnick J, Osborne MP, Van Zee K.
Predictors of intrusive thoughts and avoidance in women with family histories of breast cancer.
Annals of Behavioral Medicine 1997;19:362-369

100. Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM,
Brown AMC.
Isolation of two novel WNT genes, WNT 14 and WNT 15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.
Genomics 1997;46:450-458.

101. Robson M, Dabney MK, Rosenthal G, Ludwig S, Seltzer MH, Gilewski T, Haas B, Osborne MP, Norton L, Gilbert F, Offit K.
Prevalence of recurring BRCA mutations among Ashkenazi Jewish women with breast cancer.
Genetic Testing 1997;1:47-51

102. Wong GYC, Bradlow L, Sepkovic D, Mehl S, Mailman J, Osborne MP.
Dose-ranging study of indole-3-carbinol for breast cancer prevention.
Journal of Cellular Biochemistry 1997;Supplements 28/29:111-116

103. Telang NT, Inoue S, Bradlow HL, Osborne MP.
Negative growth regulation of oncogene-transformed mammary epithelial cells by tumor inhibitors.
Advances in Experimental Medicine and Biology 1997;400A:409-418

104. Gilbert F, Dabney MK, Diemer K, Ludwig S, Rosenthal G, Osborne MP.
BRCA1/BRCA2 mutations and breast cancer in Ashkenazi Jewish women.
Annals of the New York Academy of Sciences 1997;833:198-203.

105. Davis DL, Telang NT, Osborne MP, Bradlow HL.
Medical hypothesis: bifunctional genetic-hormonal pathways to breast cancer.
Environmental Health Perspectives 1997;105, Suppl3:571-576.

106. Telang NT, Arcuri F, Granata OM, Bradlow HL, Osborne MP, Castagnetta L.
Alteration of oestradiol metabolism in myc oncogene-transfected mouse mammary epithelial cells.
British Journal of Cancer 1998; 77:1549-1554

107. Bradlow HL, Sepkovic DW, Klug T, Osborne MP.
Application of an improved ELISA assay to the analysis of urinary estrogen metabolites.
Steroids 1998; 63:406-413

108. Giess CS, Keating DM, Osborne MP, Ng YY, Rosenblatt R.
Retroareolar breast carcinoma: clinical, imaging, and histopathologic features.
Radiology 1998; 207: 669-673

109. Breuer B, Smith S, Thor A, Edgerton S, Osborne MP, Minick R, Cody HS 3rd, Nowak E, Cortese A, Simmons RM, Carney WP, Brandt-Rauf PW.
ErbB-2 protein in sera and tumors of breast cancer patients.
Breast Cancer Research Treatment 1998;49:261-70

110. Oliveria S, Christos PJ, Visintainer PF, McDougall CJ, Osborne MP.
Patterns of colon cancer screening among companies in the U.S.: A descriptive survey.
American Journal of Health Promotion 1999;13:146-148.

111. Jinno H, Steiner MG, Mehta RG, Osborne MP, Telang NT.
Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu oncogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl) retinamide.
Carcinogenesis 1999;20:229-236.

112. Yagmur Y, Prasad MJ, Osborne MP.
Myofibroblastoma in the irradiated breast.
Breast Journal 1999;5:136-140.

113. Taioli E, Bradlow HL, Garbers VV, Sepkovic DW, Osborne MP, Trachman J, Ganguly S, Garte SJ.
Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.
Cancer Detection and Prevention 1999;23:232-237.

114. Giess CS, Keating DM, Osborne MP, Rosenblatt R.
Local tumor recurrence following breast-conservation therapy: Correlation of histopathologic findings with detection method and mammographic findings.
Radiology 1999;212:829-835.

115. Suto A, Telang NT, Tanino H, Takeshita T, Ohmiya H, Osborne MP, Kubota T.
In vitro and in vivo modulation of growth regulation in the human breast cancer cell line MCF-7 by estradiol metabolites.
Breast Cancer – Journal of the Japanese Breast Cancer Society 1999;6:87-92

116. Simmons RM, Fish SK, Gayle L, LaTrenta GS, Swistel A, Christos P, Osborne MP. Local and distant recurrence rates in skin-sparing mastectomies compared with non-skin-sparing mastectomies.
Annals of Surgical Oncology 1999;6:676-681

117. Simmons RM, Osborne MP.
The evaluation of high risk and pre-invasive breast lesions and the decision process for follow up and surgical intervention.
Surgical Oncology 1999;8:55-65

118. Prasad ML, Osborne MP, Giri DD, Hoda SA.
Microinvasive Carcinoma (T1mic) of the Breast: Clinicopathologic Profile of 21 Cases.
American Journal of Surgical Pathology 2000;24:422-428.

119. Shin SJ, Osborne MP, Moore A, Hayes MK, Hoda SA.
Determination of size in invasive breast carcinoma: Pathologic considerations and clinical implications.
American Journal of Clinical Pathology 2000;113:19-S29

120. Saqi A, Osborne MP, Rosenblatt R, Shin SJ, Hoda SA.
Quantifying mammary duct carcinoma in situ: A wild goose chase?
American Journal of Clinical Pathology 2000;113:30-S37

121. Rivadeneira DE, Simmons RM, Christos PJ, Hanna K, Daly JM, Osborne MP.
Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: Analysis in more than 900 patients.
Journal of the American College of Surgeons 2000;191:1-8

122. Rivadeneira DE, Simmons RM, Fish SK, Gayle L, La Trenta GS, Swistel A, Osborne MP.
Skin-sparing mastectomy with immediate breast reconstruction: A critical analysis of local recurrence.
Cancer Journal 2000;6:331-35

123. Telang NT, Katdare M, Bradlow HL, Osborne MP.
Cell cycle regulation, apoptosis and estradiol biotransformation: novel endpoint biomarkers for human breast cancer prevention.
Journal of Clinical Ligand Assay 2000;23:130-137

124. Giess CS, Keating DM, Osborne MP, Mester J, Rosenblatt R.
Comparison of rate of development and rate of change for benign and malignant breast calcifications at the lumpectomy bed.
American Journal of Roentgenology 2000;175:789-93.

125. Rosenbaum Smith SM, Osborne MP.
Breast cancer chemoprevention.
American Journal of Surgery 2000;180:249-251

126. Simmons R, Hoda S, Osborne MP.
Bone marrow Micrometastases in breast cancer patients.
American Journal of Surgery 2000;180:309-312

127. Shaikh N, LaTrenta G, Swistel A, Osborne MP.
Detection of recurrent breast cancer after tram flap reconstruction.
Annals of Plastic Surgery 2001; 47:602-607

128. Simmons RM, Brennan MB, Christos P, Sckolnick M, Osborne MP.
Recurrence rates in patients with central or retroareolar breast cancers treated with mastectomy or lumpectomy.
American Journal of Surgery 2001; 182:325-329

129. Simmons RM, Smith SM, Osborne MP.
Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization.
Breast Journal 2001; 7:181-183

130. Simmons R, Brennan M, Christos P, King V, Osborne MP.
Analysis of nipple/areolar involvement with mastectomy: Can the areola be preserved?
Annals of Surgical Oncology 2002; 9:165-168

131. Jinno H, Steiner MG, Nason-Burchenal K,Osborne MP, Telang NT.
Preventive efficacy of receptor class selective retinoids on HER-2/neu oncogene expressing preneoplastic human mammary epithelial cells.
International Journal of Oncology 2002; 21:127-134

132. Katdare M, Osborne MP, Telang NT
Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells.
International Journal of Oncology 2002; 21:809-815

133. Hoda SA, Chiu A, Resetkova E, Harigopal M, Hoda RS, Osborne MP
Pathological Examination of Sentinel Lymph Node in Breast Cancer: Potential Problems and Possible Solutions.
Microscopy Research and Technique 2002; 59:85-91

134. Katdare M, Osborne MP, Telang NT
Novel cell culture models for prevention of human breast cancer (Review)
International Journal of Oncology 2003: 22:509-515

135. Simmons R and Osborne MP
Diseases of the Breast
Rakel and Bope: Conn’s Current Therapy 2003; 1125-1130

136. Simmons R, Adamovich T, Brennan M, Christos P, Schultz M, Eisen C, Osborne MP
Nonsurgical Evaluation of Pathologic Nipple Discharge.
Annals of Surgical Oncology 2003; 10:113-116


CONTACT INFORMATION

Mailing address:

Strang Cancer Prevention Center
428 East 72nd Street
New York, NY 10021

Telephone
:
(212) 746-6629

Fax:
(212) 396-1244

E-mail:
osborne@strang.org


 


July 18, 2005 10:42
Copyright 2003 Strang Cancer Prevention Center

All rights reserved


Charles E. Potter, CIO