Nitin T. Telang, Ph.D.
Julian H. Robertson Jr. Carcinogenesis and Prevention Laboratory

Research Summary
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RESEARCH SUMMARY

COLON CANCER CHEMOPREVENTION PROGRAM

The ongoing research activity in this laboratory is focused on identifying pharmaceutical and nutraceutical agents effective in prevention of human colon cancer. Recently developed cell culture systems and novel biomarker assays specific for early events in cancer development are utilized as a preclinical approach for cancer chemoprevention.
Epithelial cells at risk for carcinogenesis due to abnormal expression of oncogenes or impaired expression of tumor suppressor genes exhibit enhanced growth, inhibition of cell death (apoptosis) and develop tumors. Several classes of synthetic pharmacological agents and natural phytochemicals present in green vegetables, green tea, soy products, non-fractionated extracts from edible plants and from medicinal herbs are evaluated for their preventive efficacy. These agents are effective in inhibiting aberrant cell cycle progression and inducing apoptosis, thereby decreasing the risk of tumor development.
Recent research funded in part by National Cancer Institute and Strang Philanthropic Funds has developed new preclinical models for sporadic, familial and hereditary colon cancer. Subculturable epithelial cell lines with abnormal APC tumor suppressor genes or DNA-mismatch repair genes are being characterized for molecular, biochemical and cellular risk for carcinogenesis and susceptibility to chemoprevention.
The present preclinical models for prevention of human colon carcinogenesis represent a rapid screen to identify new compounds for future clinical investigations on asymptomatic “high risk” population and on cancer patients.

SELECTED  RECENT  PUBLICATIONS

Jinno H, Steiner MG, Mehta RG, Osborne MP, Telang NT (1999). Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu onogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl) retinamide. Carcinogenesis 20:229-236.

Katdare M, Jinno H, Osborne MP, Telang NT (1999). Negative growth regulation of oncogene-transformed human breast epithelial cells by phytochemicals: Role of apoptosis. Ann. NY Acad. Sci. 889: 247-252.

Telang NT, Katdare M, Bradlow HL, Osborne MP (2000). Cell cycle regulation, apoptosis and estradiol biotransformation: Novel endpoint biomarkers for human breast cancer prevention. J. Clin. Ligand Assay 23: 130-137.

Katdare M, Kopelovich L, Telang NT (2001). Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc1638 [+/-] mouse. Ann. NY Acad. Sci. 952: 169-174.
Katdare M, Kopelovich L, Telang NT (2002). Efficacy of chemopreventive agents for growth inhibition of Apc1638 [+/-]COL colonic epithelial cells. Int.J.Mol.Med.10;427-432.

Telang NT, Kopelovich L, Katdare M (2002). Novel preclinical cell culture models for human familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon cancer (HNPCC) syndromes. Amer. Assoc. Cancer Res. 43: 1007 (Abst. #4991).

Katdare M, Kopelovich L., Telang NT (2002). Preventive efficacy of 9cis-Retinoic acid on mutant colon epithelial cell lines established from Apc1638N [+/-] and MLH1 [+/-]/Apc1638N [+/-] gene knock out mice. Proc.Amer.Assoc.CancerRes.43:124 (Abst. # 624).

Katdare M, Ishizuka H, Telang NT (2002). Cox independent modulation of growth by Sulindac in epithelial cell culture model for human familial adenomatous polyposis (FAP) syndrome. Proc. Amer. Assoc. Cancer Res., 43: (Abst. # LB25).
Telang NT, Katdare M (2003). Preventive modulation of colon carcinogenesis: a cell culture approach. Int. J. Mol. Med., 12 (suppl. 1): S19 (Abst. # 160).